Inhibition of quorum sensing-mediated processes in bacteria
AssigneeThe Trustees of Princeton University
InventorsBonnie Bassler, Lee Swem
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Abstract
Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.
Claims26
An isolated compound characterized by its ability to bind to Vibrio harveyi LuxN at the autoinducer-1 (AI-1) binding site of LuxN, wherein said compound is of the structures from the group consisting of:
A method of disrupting detection of acyl-homoserine lactone-type autoinducer in Gram-negative bacteria comprising contacting the bacteria with a compound whose structure is
A method of inhibiting bacterial infection of a host comprising contacting the bacteria with a compound whose structure is
- wherein the bacteria are gram-negative quorum sensing bacteria.
Dependencies are inferred from the claim text.