# US 8,568,752 B2 · Treatment and composition for achieving skin anti-aging benefits by corneum protease activation

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- Number: US 8,568,752 B2
- Document ID: US8568752B2
- Status: Granted
- Kind: B2
- Application number: 13/852,542
- Filed: 2013-03-28
- Published: 2013-08-15
- Granted: 2013-10-29
- Earliest claimed: 1999-07-20
- Assignees: Mary Kay Inc.
- Applicants: Mary Kay, Inc.
- Inventors: John R. Schultz
- Web page: https://patentgrep.com/patent/US8568752B2

## CPC

- A61K 8/40: containing nitrogen (quinones containing nitrogen A61K8/355)
- A61K 8/042: {Gels}
- A61K 8/062: {Oil-in-water emulsions}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate}
- A61K 8/55: Phosphorus compounds
- A61K 8/676: {Ascorbic acid, i.e. vitamin C}
- A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof}
- A61K 8/8147: {Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers}
- A61K 8/922: {of vegetable origin}
- A61K 8/9706: Algae
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61P 17/00: Drugs for dermatological disorders
- A61Q 19/007: {Preparations for dry skin}
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/30: Characterized by the absence of a particular group of ingredients
- A61K 2800/51: Chelating agents
- A61K 2800/59: Mixtures
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed is a method of brightening skin or evening out the tone of skin comprising topically applying to skin in need thereof a composition comprising a chemically compatible combination of one or more surfactants and at least one chelating agent, ascorbic acid or a derivative thereof, algae extract, and kelp or sodium sulfite and sodium metabisulfite.

## Claims

### Claim 1

A method of brightening skin or evening out the tone of skin comprising topically applying to skin in need thereof a composition comprising:
(i) a chemically compatible combination of one or more surfactants and at least one chelating agent;
(ii) ascorbic acid or a derivative thereof;
(iii) algae extract; and
(iv) kelp or sodium sulfite and sodium metabisulfite.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition is an emulsion.

### Claim 3 (depends on 2)

The method of claim 2, wherein the emulsion is an oil-in-water emulsion.

### Claim 4 (depends on 1)

The method of claim 1, wherein the composition is a cream, a lotion, or a solution.

### Claim 5 (depends on 1)

The method of claim 1, wherein the ascorbic acid derivative is an ester of ascorbic acid.

### Claim 6 (depends on 1)

The method of claim 1, wherein the chelating agent is EDTA, disodium EDTA or EGTA.

### Claim 7 (depends on 1)

The method of claim 1, wherein the composition comprises kelp.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition comprises sodium sulfite and sodium metabisulfite.

### Claim 9 (depends on 8)

The method of claim 8, wherein the composition further comprises water, butylene glycol, and benzyl salicylate.

### Claim 10 (depends on 9)

The method of claim 9, wherein the composition further comprises glycerin and propylene glycol.