Water-soluble drug carrier and process for producing the same
AssigneeKyushu University, National University Corporation
InventorsMasahiro Goto, Noriho Kamiya, Yoshiro Tahara
Life of this patent
Estimating the term…
Abstract
An object of the present invention is to provide a drug delivery carrier that is free from the drug leakage problem and has an easily controllable particle size, and that can be used to deliver water-soluble drugs such as genes and proteins in a wide range of applications, including delivery of water-soluble drugs that do not have high anionic properties, and also can be used as a non-viral gene vector. The invention also provides a process for production of such drug delivery carriers. The drug delivery carrier of the present invention includes a water-soluble drug double-coated with two types of inner and outer surfactants 1 and 2.
Claims5
A process for producing a drug delivery carrier that includes a water-soluble drug double-coated with two types of inner and outer surfactants 1 and 2, the process comprising the steps of:
- 1) mixing and agitating a water-soluble drug-containing aqueous phase with an oily phase containing the surfactant 1 to form a W/O emulsion in which the water-soluble drug-containing aqueous phase is dispersed in the oily phase;
- 2) removing the inner aqueous phase from the W/O emulsion to form a S/O in which the water-soluble drug coated with the surfactant 1 is dispersed in the oily phase;
- 3) mixing and agitating the S/O with an aqueous phase containing the surfactant 2 to form a S/O/W emulsion in which the S/O is dispersed in the aqueous phase;
- and
- 4) removing the inner oily phase from the S/O/W emulsion to form a S/W in which the water-soluble drug coated with the surfactant 1 and the surfactant 2 is dispersed in the aqueous phase,
- wherein the inner surfactant 1 is at least one member selected from the group consisting of:
- sucrose erucate ester and sucrose laurate ester;
- and the outer surfactant 2 is at least one member selected from the group consisting of:
- PC, sucrose laurate ester L-1695, PEG (2K)-DSPE, PEG(5K)-DSPE, PEG(comb)-DSPE, polysorbate 80, sodium dodecyl sulfate, and glycerin fatty acid ester.
Dependencies are inferred from the claim text.