L-Threonine derivatives of high therapeutic index

A method for enhancing the therapeutic index of a drug having a functionality group selected form the group consisting of hydroxy, carboxy or acylating derivatives of said carboxy group

• the method comprising administering to a mammal a L-Threonine ester of said drug, wherein the drug is Abacavir, Acarbose, Acebutolol, Acetaminophen, Adefovir, Albuterol, Alfaprostol Acid, Amoxicillin, Amphotericin B, Amprenavir, Arachidonic Acid, Aspirin, Atenolol, Atorvastatin, Atropine, Atovaquone, Baclofen, Benazeprilat, Beraprost, Betaxolol, Bexarotene, Bicalutamide, Biotin, Biperiden, Bisoprolol, Bitolterol, Brinzolamide, Buprenorphine, Butorphanol, Candesartan, Capacitabine, Captopril, Carbidopa, Carboprost, Carnitine, Carteolol, Carvedilol, Cefdinir, Cefditoren, Ceftazimide, Cefpodoxime, Cefuroxime, Cerivastatin, Chloramphenicol, Ciprofloxacin, Clopidogrel Acid, Cloprostenol, Clorazepic Acid, Cyclosporine, Cytarabine, Danazol, Dextroamphetamine, Diclofenac, Didanosine, Digoxin, Divalproex, Docetaxel, Dyphylline, Enalaprilat, Ephedrine, Eplerenone, Eprosartan, Esmolol, Estramustine, Ethambutol, Ethchlorvynol, Etoposide, Ezetimibe, Fenofibrate, Fenoprofen, Fenprostalene Acid, Fexofenadine, Fibric Acid derivatives, Fluprostenol, Flurbiprofen, Fluticasone, Fluvastatin, Folic Acid, Fosinoprilat, Frovatriptan, Fulvestrant, Gabapentin, Gemprost Acid, Ganciclovir, Goserelin, 5-HETE, Hydroxychloroquine, Hydroxyzine, Hyoscyamine, Ibuprofen, Ibutilide, Indinavir, Ipratropium, Irinotecan, Isosorbide, Ketoprofen, Ketorolac, Labetalol, Lamivudine, Lansoprazole, Latanoprost Acid, Leuprolide, Leukotrienes, Levobunolol, Levodopa, Levorphanol, Υ-Linolenic Acid, Limaprost, Liothyronine, Lisinopril, Lopinavir, Lorazepam, Lovastatin, Medroxyprogesterone, Mefloquine, Megestrol, Metaproterenol, Methohexital, Methotrexate, Methylphenidate, Methylprednisolone, Metoprolol, Mexiletine, Miglitol, Moexiprilat, Mometasone, Montelukast, Mycophenolate Acid, Nadolol, Nalbuphine, Naproxen, Nateglinide, Nelfinavir, Niacin, Nicotinic Acid, Norgestimate, Octreotide, Ofloxacin, Olmesartan, Ozagrel, Paclitaxel, Pantothenic Acid, Penbutolol, Penicillamine, Penciclovir, Pentazocine, Perindoprilat, Phenylephrine, Phenylpropanolamine, Pimecrolimus, Pindolol, Pirbuterol, Pravastatin, Propafenone, Propofol, Propranolol, Prostgandins E1, E2 and F2α, Prostanoic Acid, Pseudoephedrine, Quinaprilat, Quinidine, Quinine, Ramiprilat, Repaglinide, Ribavirin, Ritonavir, Rosaprostol, Rosuvastatin, Salmeterol, Salicylic Acid, Salsalate, Simavastatin, Sirolimus, Sotalol, Sulfa Drugs, Sulfasalazine, Tacrolimus, Tazorotene, Telmesartan, Tenofovir, Terbutaline, Thyroxine, Tiagabine, Timolol, Tirofiban, Tramadol, Trandolaprilat, Tranylcypromine, Treprostinil, Triamcinolone, Trimoprostil, Troglitazone, Unoprostone, Valsartan, Valproic Acid, Venlafaxine, Vidarabine, Warfarin, Zalcitabine, or Zidovudine, wherein said L-Threonine ester of said drug has an enhanced therapeutic index relative to said drug.