Methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy

A method of reducing triglyceride levels in a subject on statin therapy and having a triglyceride level of 500 mg/dl to 1500 mg/dl comprising, administering to the subject 2000 mg to 5000 mg per day of ethyl eicosapentaenoate for 12 weeks to reduce triglycerides in the subject without substantially increasing LDL-C compared to subjects having a triglyceride level of 500 mg/dl to 1500 mg/dl who receive a statin but no ethyl eicosapentaenoate for 12 weeks.