Azepine inhibitors of Janus kinases

A compound of Formula Ia, Ib, or Ic:

• or pharmaceutically acceptable salt thereof, wherein:
• D1, D2, D3, D4, D5, D6 and D7 are, independently, CR1 or N;
• E is O, S, SO, SO2, or NR2a;
• G is N or CR2b;
• Q1 and Q2 are each, independently, N or CR2c;
• W1 is absent, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, O, S, NR3, CO, COO, CONR3, SO, SO2, SONR3, SO2NR3, or NR3CONR4, wherein said C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl is optionally substituted by 1, 2 or 3 substituents independently selected from halo, OH, C1-4 alkoxy, C1-4 haloalkoxy, amino, C1-4 alkylamino and C2-8 dialkylamino;
• W2 is absent, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl is optionally substituted by 1, 2, or 3 substituents independently selected from halo, CN, NO2, OH, ═NH, ═NOH, ═NO—(C1-4 alkyl), —NR3C(O)O—(C1-4 alkyl), NR3C(O)—(C1-4 alkyl), —C(O)O—(C1-4 alkyl), C1-4 halo alkyl, C1-4 cyanoalkyl, pentahalosulfanyl, C1-4 hydroxylalkyl, C1-4 alkylthio, C1-4 haloalkylthio, C1-4 alkoxy, C1-4 haloalkoxy, amino, C1-4 alkylamino and C2-8 dialkylamino;
• W3 is absent, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, O, S, NR3, ═N—, ═N—O—, ═N—O—(C1-4 alkyl)-, O—(C1-4 alkyl), S—(C1-4 alkyl), NR3—(C1-4 alkyl), (C1-4 alkyl)-O-(C1-4 alkyl), (C1-4 alkyl)-S—(C1-4 alkyl), (C1-4 alkyl)-NR3—(C1-4 alkyl), CO, COO, C(O)—(C1-4 alkyl), C(O)O—(C1-4 alkyl), C(O)—(C1-4 alkyl)-C(O), NR3C(O)—(C1-4 alkyl), C(O)NR3—(C1-4 alkyl), NR3C(O)O—(C1-4 alkyl), NR3C(O)O, CONR3, SO, SO2, SONR3, SO2NR3, or NR3CONR4, wherein said C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl is optionally substituted by 1, 2 or 3 substituents independently selected from halo, OH, CN, C1-4 alkoxy, C1-4 haloalkoxy, amino, C1-4 alkylamino and C2-8 dialkylamino;
• W4 is H, NR3R4, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl, wherein each of said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, OH, CN, C1-4 alkoxy, ═NH, ═NOH, ═NO—(C1-4 alkyl), C1-4 haloalkyl, C1-4 haloalkoxy, pentahalosulfanyl, COOH, CONH2, COO—(C1-4 alkyl), amino, C1-4 alkylamino and C2-8 dialkylamino;
• R1 is, independently, H, halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, NRcC(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, NRcS(O)NRcRd, pentahalosulfanyl, S(O)2Rb, or S(O)2NRcRd;
• R2a is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, C1-4 alkoxy, C(O)Rb, C(O)NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, or S(O)2NRcRd;
• R2b and R2c are each, independently, H, halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcC(O)NRcRd, NRcRd, NRcC(O)Rd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, NRcS(O)NRcRd, S(O)2Rb, or S(O)2NRcRd;
• R3 and R4 are each, independently, H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, arylalkyl, cycloalkylalkyl, COORa′, CORb′, SORb′, or SO2Rb′ wherein each of said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, arylalkyl, or cycloalkylalkyl is optionally substituted by 1, 2 or 3 substituents selected from halo, C1-4 alkyl, C1-4 haloalkyl, OH, C1-4 alkoxy, C1-4 haloalkoxy, amino, C1-4 alkylamino, C2-8 dialkylamino, aminocarbonyl, C1-4 alkylaminocarbonyl, C2-8 dialkylaminocarbonyl, CN and NO2;
• or R3 and R4 together with the N atom to which they are attached form a heterocycloalkyl group optionally substituted by 1, 2 or 3 substituents selected from halo, C1-4 alkyl, C1-4 haloalkyl, OH, C1-4 alkoxy, C1-4 haloalkoxy, amino, C1-4 alkylamino, C2-8 dialkylamino, aminocarbonyl, C1-4 alkylaminocarbonyl, and C2-8 dialkylaminocarbonyl;
• Ra and Ra′ are each, independently, H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl;
• Rb and Rb′ are each, independently, H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl;
• and
• Rc and Rd are each, independently, H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, arylalkyl, or cycloalkylalkyl;
• or Rc and Rd together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group;
• provided that when D7 is N, E is O or S, and G is N;
• then —W1—W2—W3—W4 is other than H.