Targeting of antigen presenting cells with immunonanotherapeutics

A method comprising administering a first dose of a composition comprising

• synthetic nanocarriers having at least one surface, wherein a first surface of the synthetic nanocarriers comprises an immunofeature surface formed of an array of binding moieties, the array binding to antigen presenting cell surfaces with high avidity and low affinity as compared to antibody binding;
• a tolerance inducing agent selected from the group consisting of immunosuppressants and agents that induce regulatory T cells to promote tolerance to an antigen;
• and
• a pharmaceutically acceptable excipient to a subject.

A method of eliciting tolerance in a humoral immune response, the method comprising administering an effective amount of a composition comprising

• synthetic nanocarriers having at least one surface, wherein a first surface of the synthetic nanocarriers comprises an immunofeature surface formed of an array of binding moieties, the array binding to antigen presenting cell surfaces with high avidity and low affinity as compared to antibody binding;
• a tolerance inducing agent selected from the group consisting of immunosuppressants and agents that induce regulatory T cells to promote tolerance to an antigen;
• and
• a pharmaceutically acceptable excipient.