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US 8,562,997 B2Granted
Methods of treating acute myeloid leukemia by blocking CD47
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSiddhartha Jaiswal, Irving L. Weissman, Ravindra Majeti, Mark P. Chao
Life of this patent
Estimating the term…
Abstract
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
Claims2
A method of treating a human subject having acute myeloid leukemia (AML), the method comprising:
- administering to the human subject an antibody that prevents the binding of CD47 with SIPRα, at a dose that achieves a depletion in circulating AML stem cells (AMLSC).
Dependencies are inferred from the claim text.