Methods for manipulating satiety
AssigneeCedars-Sinai Medical Center
InventorHenry C. Lin
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Abstract
Various embodiments of the invention disclosed herein include methods of inducing satiety a mammal in need thereof. Also disclosed are methods of inducing satiety in an obese mammal. Additionally disclose are method of suppressing appetite in a mammal in need thereof. Further disclosed are methods of treating obesity. The methods described herein involve the administration of serotonin, a serotonin agonist or a serotonin re-uptake inhibitor to the mammal.
Claims26
A method of weight management in a mammal in need thereof, comprising:
- providing a composition comprising a serotonin receptor agonist, and a pharmaceutically acceptable carrier or an excipient;
- and
- administering the composition to the mammal, whereby weight loss is induced in the mammal by the serotonin receptor agonist activating, in the gastrointestinal tract, the cholinergic intestino-fugal pathway, at least one prevertebral ganglionic pathway, the adrenergic efferent neural pathway, the serotonergic interneuron and/or the opioid interneuron.
A method of inducing satiety in a mammal in need thereof, comprising:
- providing a composition comprising a serotonin receptor agonist, and a pharmaceutically acceptable carrier or an excipient;
- and
- administering the composition to the mammal, whereby a state of satiety is induced in the mammal by the serotonin receptor agonist activating, in the gastrointestinal tract, the cholinergic intestino-fugal pathway, at least one prevertebral ganglionic pathway, the adrenergic efferent neural pathway, the serotonergic interneuron and/or the opioid interneuron.
A method of suppressing appetite in a mammal in need thereof, comprising:
- providing a serotonin receptor agonist;
- and
- administering the serotonin receptor agonist to the mammal, whereby the appetite is suppressed in the mammal by the serotonin receptor agonist activating, in the gastrointestinal tract, the cholinergic intestino-fugal pathway, at least one prevertebral ganglionic pathway, the adrenergic efferent neural pathway, the serotonergic interneuron and/or the opioid interneuron.
A method of treating obesity in a mammal in need thereof, comprising:
- providing a serotonin receptor agonist;
- and
- administering the serotonin receptor agonist to the mammal, whereby obesity is treated in the mammal by the serotonin receptor agonist activating, in the gastrointestinal tract, the cholinergic intestino-fugal pathway, at least one prevertebral ganglionic pathway, the adrenergic efferent neural pathway, the serotonergic interneuron and/or the opioid interneuron.
Dependencies are inferred from the claim text.