2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative, production method thereof, and production method of monofluoromethyl group-containing compound using the same

A method for producing a monofluoromethyl group-containing compound represented by the following formula (6),

• wherein:
• R5 represents a hydrogen atom, a methyl group, an ethyl group, a straight-chain, branched, or cyclic alkyl group having 3 to 10 carbon atoms, an optionally-substituted phenyl group, a 1-naphthyl group, or a 2-naphthyl group;
• and
• R6 represents a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a benzyl group;
• the method comprising:
• (1) first producing a 2-substituted-2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide compound represented by the following formula (4),
• wherein:
• R1, R2, R3, and R4 are each a hydrogen atom;
• R5 and R6 are as defined above;
• and
• R7 is an acetoxy group,
• by reacting, in the presence of a metal catalyst, an acetate represented by the following formula (3),
• wherein R5, R6, and R7 are as defined above,
• with a 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide compound represented by the following formula (1),
• wherein R1, R2, R3, and R4 are as defined above,
• to obtain the 2-substituted-2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide compound represented by the formula (4), and
• (2) then hydrolyzing the compound represented by the formula (4) to obtain the monofluoromethyl group-containing compound represented by the formula (6).