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US 8,558,009 B2Granted
Pyrroles having hypolipidemic hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them and their use in medicine
AssigneeCadila Healthcare Limited
InventorsBraj Bhushan Lohray, Vidya Bhushan Lohray, Vijay Kumar Barot, Saurin Khimshankar Raval, Preeti Saurin Raval, Sujay Basu
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Abstract
The present invention relates to compounds of the general formula (I) their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, wherein all variables are as defined in the specification.
Claims16
A compound of formula (I)
- their tautomeric forms, their stereoisomers, and their pharmaceutically acceptable salts, wherein R2 and R3 represent hydrogen, and R1 is methyl, R4 may be same or different, and represent hydrogen, cyano, or substituted or unsubstituted groups selected from linear (C1-C6)alkyl, branched (C1-C6)alkyl, aryl, aralkyl, heterocyclyl, heteroaryl, heterocyclyl(C1-C6)alkyl, heteroar(C1-C6)alkyl, acyl, acyloxy, mono-substituted or di-substituted aminoalkyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, (C1-C6)alkylthio, thio(C1-C6)alkyl, arylthio;
- n represents an integer 2, W represents O;
- Ar represents a substituted or unsubstituted divalent single or fused aromatic, heteroaromatic group;
- R5 and R6 represent both hydrogen or together represent a bond;
- X represents O;
- R7 represents hydrogen, substituted or unsubstituted groups selected from linear and branched (C1-C12)alkyl;
- Y represents O;
- Z represents O;
- R8 represents hydrogen, substituted or unsubstituted groups selected from linear (C1-C6)alkyl and branched (C1-C6)alkyl.
6 more elements
Dependencies are inferred from the claim text.