Compounds for the treatment of addiction
AssigneeGilead Sciences, Inc.
InventorsCarina E. Cannizzaro, Michael Graupe, Juan A. Guerrero, Yafan Lu, Robert G. Strickley, Chandrasekar Venkataramani, Jeff Zablocki
Life of this patent
Estimating the term…
Abstract
Disclosed are novel compounds having the structure of Formula (I): which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.
Claims3
A compound of Formula (Ia):
- wherein:
- R1 is hydrogen, optionally substituted C1-6 alkyl, —CH2OH, —CH2OP(O)(OR20)(OR21), —C(O)R22, or —SO2R23;
- R2 is hydrogen, optionally substituted C1-6 alkyl, C3-C6 cycloalkyl, or halo;
- each of R3, R4, R5, R6, R9, R10, R11, R12 and R13 is independently hydrogen, hydroxyl, —OP (O)(OR20)(OR21), —CH2OH, —CH2OP(O)(OR20)(OR21), optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkylene, optionally substituted C2-C6 alkynyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C6 cycloalkyl, aminocarbonyl, acyl, acylamino, —O—(C1 to C6-alkyl)—O—(C1 to C6-alkyl), cyano, halo, —SO2NR24R25;
- or —NR24R25;
- R7 is hydrogen or optionally substituted C1-6 alkyl;
- each of R20 and R21 is independently Na+, Li+, K+, hydrogen, C1-6 alkyl;
- or R20 and R21 can be combined to represent a single divalent cation Zn2+, Ca2+, or Mg2+.
- each of R22 and R23 is independently optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C6 cycloalkyl, optionally substituted aryl, or —NR24R25;
- and
- each of R24 and R25 is independently chosen from hydrogen or C1-6 alkyl or when combined together with the nitrogen to which they are attached form a heterocycle;
- or
- a pharmaceutically acceptable salt, ester, single stereoisomer, mixture of stereoisomers, or tautomer thereof.
A compound of formula (I)
- wherein:
- R1 is hydrogen, optionally substituted C1-6 alkyl, —CH2OH, —CH2OP(O)(OR20)(OR21);
- R2 is hydrogen, optionally substituted C1-6 alkyl, C3-C6 cycloalkyl, or halo;
- each of R3, R4, R5, R6, R9, R10, R11, R12 and R13 is independently hydrogen, hydroxyl, —OP(O)(OR20)(OR21), —CH2OH,)—CH2OP(O)(OR20(OR21), optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkylene, optionally substituted C2-C6 alkynyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C6 cycloalkyl, aminocarbonyl, acyl, acylamino, —O—(C1 to C6-alkyl)—O—(C1 to C6-alkyl), cyano, halo, —SO2NR24R25;
- or —NR24R25;
- R7 is hydrogen or optionally substituted C1-6 alkyl;
- each of R20 and R21 is independently Na30, Li30, K30, hydrogen, C1-6 alkyl;
- or R20 and R21 can be combined to represent a single divalent cation Zn2+, Ca2+, or Mg2+,
- each of R22 and R23 is independently optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C6 cycloalkyl, optionally substituted aryl, or —NR24R25;
- and
- each of R24 and R25 is independently chosen from hydrogen or C1-6 alkyl or when combined together with the nitrogen to which they are attached form a heterocycle;
- or
- a pharmaceutically acceptable salt, ester, single stereoisomer, mixture of stereoisomers, or Tautomer thereof.
Dependencies are inferred from the claim text.