4-pyridinone compounds and their use for cancer
AssigneeBristol-Myers Squibb Company
InventorsRobert C. Livingston, William P. Gallagher
Life of this patent
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Abstract
Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed.
Claims8
A process for preparing a compound of Formula (I)
- comprising the steps of
- (a) reacting a carboxylic acid compound of Formula (III):
- or an activated carboxylic acid compound therefor, and an aniline compound of Formula (II):
- wherein PAm is a protected amine group, to provide a compound of Formula (IV):
- and
- (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I).
A process for preparing a compound of Formula (Ia) having the structure:
- comprising the steps of:
- (a) reacting a carboxylic acid compound of Formula (IIIa):
- or an activated carboxylic acid compound thereof, and an aniline compound of Formula (IIb):
- wherein PAm is a protected amine group, to provide a compound of Formula (IVb):
- and
- (b) converting said protected amine group attached to said compound of Formula (IVb) to an amine group to provide said compound of Formula (Ia).
A process for preparing a prodrug having the structure:
- comprising the steps of:
- (a) reacting a carboxylic acid compound of Formula (IIIb):
- or an activated carboxylic acid compound thereof, and an aniline compound of Formula (IIb):
- wherein PAm is a protected amine group, to provide a compound of Formula (IVb):
- (b) converting said protected amine group attached to said compound of Formula (IVb) to an amine group to provide a compound of Formula (Ib);
- and
- (c) converting said compound of Formula (Ib) to said prodrug.
Dependencies are inferred from the claim text.