Imidazo [4, 5-C] quinoline derivatives as bromodomain inhibitors

A compound of formula (I) or a salt thereof

• wherein:
• A is a group selected from the following:
• X represents CH or N;
• Y represents CH or N with the proviso that when X is N, Y is CH;
• Rx represents O or S;
• R1 represents C1-6alkyl, C3-6cycloalkyl, a 5 or 6 membered heterocyclyl, an aromatic group or a heteroaromatic group, wherein the aromatic group or the heteroaromatic group is optionally substituted by one to three groups selected from:
• halogen, hydroxy, cyano, nitro, C1-6alkyl, C1-4alkoxy, haloC1-4alkyl, haloC1-4-alkoxy, hydroxyC1-4alkyl, C1-4-alkoxyC1-4alkyl, C1-4-alkoxycarbonyl, C1-4-alkylsulfonyl, C1-4-alkylsulfonyloxy, C1-4alkylsulfonylC1-4alkyl, C1-4-alkylsulfonamido;
• R2 is hydrogen or C1-6alkyl,
• R2a represents:
• H, C1-6alkyl, C1-6haloallyl, (CH2)mcyano, (CH2)mOH, (CH2)mC1-6alkoxy, (CH2)mC1-6haloalkoxy, (CH2)mC1-6haloalkyl (CH2)mC(O)NRaRb, (CH2)mNRaRb and (CH2)mC(O)CH3,
• (CHR6)pphenyl optionally substituted by C1-6alkyl, C1-6alkoxy, cyano haloC1-4-alkoxy, haloC1-4-alkyl,
• (CHR6)pheteroaromatic, (CHR6)pheterocyclyl,
• wherein
• Ra represents H, C1-6alkyl, or heterocyclyl;
• Rb represents H or C1-6alkyl, or
• Ra and Rb together with the N to which they are attached form a 5 or 6 membered heterocyclyl;
• R2b represents H, C1-6alkyl, (CH2)2C1-6alkoxy, (CH2)2cyano, (CH2)mphenyl, (CH2)2heterocyclyl;
• R3 represents hydrogen;
• R4 represents hydrogen, cyano or C1-6alkyl;
• Z represents O;
• or when R4 represents hydrogen and A is a group selected from (i) or (ii) and wherein Rx represents 0, Z may additionally represent NH;
• R5 represents hydrogen or C1-6alkoxy;
• R6 represents hydrogen or C1-6alkyl;
• m represents 1, 2 or 3;
• and
• n represents 0, 1 or 2
• p represents 0, 1 or 2.