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US 8,557,975 B2Granted
Methods and sequences to suppress primate Huntington gene expression
AssigneeMedtronic, Inc.
InventorsWilliam F. Kaemmerer, Michael D. Kaytor
Life of this patent
Estimating the term…
Abstract
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatto and Homo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease.
Claims22
An isolated nucleic acid duplex comprising a first strand of nucleic acid and a second strand of nucleic acid, wherein the first strand comprises at least 19 contiguous nucleotides encoded by SEQ ID NO:
- 8, and the second strand is complementary to at least 15 contiguous nucleotides within said at least 19 contiguous nucleotides of SEQ ID NO:
- 8 of the first strand.
Dependencies are inferred from the claim text.