Anti-interferon-α antibodies
AssigneeGenentech, Inc.
InventorsAnan Chuntharapai, Jin K. Kim, Leonard G. Presta, Timothy Stewart
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Abstract
The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
Claims19
An anti-IFN-α antibody comprising a heavy chain variable domain and a light chain variable domain, wherein the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO:5.
An anti-IFN-α antibody comprising a heavy chain variable domain and a light chain variable domain, wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO:3.
A composition comprising an effective amount of an anti-IFN-α antibody in admixture with a pharmaceutically acceptable carrier, wherein the antibody comprises a heavy chain variable domain and a light chain variable domain, wherein the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO:5.
A composition comprising an effective amount of an anti-IFN-α antibody in admixture with a pharmaceutically acceptable carrier, wherein the antibody comprises a heavy chain variable domain and a light chain variable domain, wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.