US 8,557,960 B2 · Peptide for augmenting and expression of BDNF and pharmaceutical composition for prevention and treatment of neurodegenerative diseases including Alzheimer's disease or Parkinson's disease, comprising the same

Abstract

Disclosed are peptides for augmenting the expression of BDNF (brain-derived neurotrophic factor) and a pharmaceutical composition for the prevention and treatment of Alzheimer's disease or Parkinson's disease, comprising the same. The peptides can induce the expression of BDNF in dopamine-reactive human cells, pass easily through the blood-brain barrier thanks to their low molecular weights and are almost free of cytotoxicity. Thus, they are useful in the prevention and treatment of neuropathies such as Alzheimer's disease or Parkinson's disease.

Claims5

Dependent claims

An isolated peptide for augmenting expression of BDNF (Brain-derived neurotrophic factor), having the following amino acid sequence:

N′-(Z1)α-Z2-(Z3)β-C′ wherein, N′ is an N-terminus of the peptide and C′ is a C-terminus of the peptide;
Z1 is G, M or R;
Z2 is D, T or V;
Z3 is F, G or Q;
α is 0 or 1;
and β is 0 or 1, with a proviso that the peptide includes at least one of Z1=M, Z2=V and Z3=G, both α and β are not 0, and the peptide is not M-V-Q, V-G, M-V and M-T.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/934,029Filed 31 Dec 2009

Priority

KR 10-2009-01069856 Nov 2009

Published

US 2012/0208747 A116 Aug 2012

Granted

15 Oct 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 38/06
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: tripeptides
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 9/10
Drugs for disorders of the cardiovascular system: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary…
A61P 25/00
Drugs for disorders of the nervous system

Peptide for augmenting and expression of BDNF and pharmaceutical composition for prevention and treatment of neurodegenerative diseases including Alzheimer's disease or Parkinson's disease, comprising the same

Life of this patent

Peptide for augmenting and expression of BDNF and pharmaceutical composition for prevention and treatment of neurodegenerative diseases including Alzheimer's disease or Parkinson's disease, comprising the same

Life of this patent

Abstract

Claims5