Gene transfer agent composition containing polyamidoamine dendron
AssigneePublic University Corporation, Osaka Prefecture University
InventorKenji Kono
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Abstract
The present invention provides a gene transfer agent, a gene transfer kit, and a gene transfer method excellent in safety and transfer efficiency. Specifically, the present invention provides a gene transfer agent composition, the gene transfer agent composition including a compound represented by any one of the following formulae DL-G1 to DL-G4: DL-G1: R1R2NX(XH2)2; DL-G2: R1R2NX(X(XH2)2)2; DL-G3: R1R2NX(X(X(XH2)2)2)2; and DL-G4: R1R2NX(X(X(X(XH2)2)2)2)2 (X represents —CH2CH2CONHCH2CH2N—), in which: R1 represents an unsaturated long-chain aliphatic group; and R2 represents an unsaturated long-chain aliphatic group or a saturated long-chain aliphatic group in the formulae.
Claims6
A gene transfer agent composition comprising a compound represented by any one of the following formulae DL-G1 to DL-G4:
- R1R2NX(XH2)2;
- DL-G1:
- R1R2NX(X(XH2)2)2;
- DL-G2:
- R1R2NX(X(X(XH2)2)2)2;
- DL-G3:
- and
- R1R2NX(X(X(X(XH2)2)2)2)2, DL-G4:
- where X represents —CH2CH2CONHCH2CH2N—,
- wherein:
- R1 represents an unsaturated long-chain aliphatic group;
- and
- R2 represents an unsaturated long-chain aliphatic group or a saturated long-chain aliphatic group in the formulae.
Dependencies are inferred from the claim text.