Inhibitors of NCCa-ATP channels for therapy
AssigneesThe United States of America as represented by the Department of Veterans Affairs, University of Maryland, Baltimore
InventorJ. Marc Simard
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Abstract
Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury, are also provided. The present invention also concerns treatment and/or prevention of intraventricular hemorrhage in infants, including premature infants utilizing one or more inhibitors of the channel is provided to the infant, for example to brain cells of the infant.
Claims8
A method of treating or preventing intraventricular hemorrhage in the brain of an infant at risk for developing intraventricular hemorrhage, comprising administering an effective amount of an inhibitor of NCCa-ATP channel to the mother prior to birth, wherein the NCCa-ATP channel inhibitor is glibenclamide.
Dependencies are inferred from the claim text.