Immunomodulatory compositions
AssigneeSummit (Wales) Limited
InventorsAlison Ann Watson, Robert James Nash, Emma Louisa Evinson
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Abstract
Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula (I), wherein R is selected from the group comprising hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups, or a pharmaceutically acceptable salt or derivative thereof, are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, haemorestoration, alleviation of immuno-suppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.
Claims11
A vaccine comprising
- (1) a polyhydroxylated pyrrolizidine compound of formula:
- wherein R is selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl, alkenyl, alkynyl, aryl groups, and a saccharide moiety,
- or a pharmaceutically acceptable salt or acyl derivative thereof, wherein said acyl derivative is selected from the group consisting of aroyl, acetyl, propanoyl and butanoyl;
- in combination with
- (2) an antigen,
- said pyrrolizidine compound being present in an amount sufficient to produce an adjuvant effect on vaccination.
Dependencies are inferred from the claim text.