(E)-N-(2-amino-phenyl)-3-{1-[4-(l-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide salts
Assignee4Sc AG
InventorsJürgen Volz, Martin Feth, Rolf-Peter Hummel, Matthias Müller, Thomas Maier, Bernd Müller
Life of this patent
Estimating the term…
Abstract
A salt of (E)-N-{2-amino-phenyl)-3-{1-[4-(1-methyl-1 H-pyrazol-4-yl)-beπzenesulfonyl]-1 H-pyrrol-3-yl)-acrylamide selected from the group consisting of the hydrobromide, methansulfonate, hemi ethane-1,2-disulfonate, benzenesulfonate, toiuenesulfonate and 2-naphthalenesulfonate.
Claims13
A salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide, which is a besylate, tosylate or 2-naphtylsulfonate salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide.
A pharmaceutical composition comprising a hydrobromide, methansulfonate, hemi ethane-1,2-disulfonate, benzenesulfonate, toluenesulfonate or 2-naphthalenesulfonate salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol -4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide and one or more pharmaceutically acceptable excipients, diluents and/or carriers.
A mesylate salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide in its polymorphic form A, which has powder X-ray diffraction peaks at:
- 3.9, 16.4 and 16.9±0.1 (°2θ);
- or
- a hemi ethane-1,2-disulfonate salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide in its polymorphic form A, which has powder X-ray diffraction peaks at:
- 16.0, 22.7 and 25.1±0.1 (°2θ);
- or
- a besylate salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide in its polymorphic form A, which has powder X-ray diffraction peaks at:
- 19.1 , 20.4 and 22.7±0.1 (°2θ);
- or
- a toluenesulfonate salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide in one of the following polymorphic forms:
- polymorphic form A, which has powder X-ray diffraction peaks at:
- 7.0, 19.6 and 19.9±0.1 (°2θ);
- polymorphic form B, which has powder X-ray diffraction peaks at:
- 18.1 , 21.2 and 22.9±0.1 (°2θ);
- polymorphic form C;
- which has powder X-ray diffraction peaks at:
- 8.9, 11.7 and 20.3±0.1 (°2θ);
- polymorphic form D, which has powder X-ray diffraction peaks at:
- 17.1, 18.7 and 22.5±0.1 (°2θ);
- polymorphic form E, which has powder X-ray diffraction peaks at:
- 6.9, 13.0 and 19.8±0.1 (°2θ);
- polymorphic form F, which has powder X-ray diffraction peaks at:
- 5.3, 10.5 and 18.6+0.1 (°2θ);
- polymorphic form G, which has powder X-ray diffraction peaks at:
- 6.6, 19.2 and 20.4±0.1 (°2θ);
- or
- polymorphic form H, which has powder X-ray diffraction peaks at:
- 6.7, 19.5 and 19.8±0.1 (°2θ);
- or
- a 2-naphtylsulfonate salt of (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide in one of the following polymorphic forms:
- polymorphic form A+B, which has powder X-ray diffraction peaks at:
- 4.6, 18.5 and 23.8 ±0.1 (°2θ);
- polymorphic form A+B, which has powder X-ray diffraction peaks at:
- 4.7, 6.8 and 18.5 ±0.1 (°2θ);
- or
- polymorphic form C, which has powder X-ray diffraction peaks at:
- 5.8, 17.3 and 22.9±0.1 (°2θ).
Dependencies are inferred from the claim text.