US 8,557,856 B2 · Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties

Abstract

The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

Claims24

Dependent claims

A compound according to formula (I)

wherein,
R1 is L1C(O)OL2C(O)OT;
R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1;
n is an integer from 0-5;
each R3 is independently halogen or R2;
L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene, wherein the backbone of alkylene may contain one or more heteroatoms;
T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenylene, C2-C10 alkynylene, nitrophenol, or cyclopropyl, wherein the backbone of alkyl may contain one or more heteroatoms;
and
pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof.

6 more elements

Dependencies are inferred from the claim text.

Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties

Life of this patent

Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties

Life of this patent

Abstract

Claims24