Use of a sulfonamide compound for improving the pharmacokinetics of a drug
AssigneeJanssen R&D Ireland
InventorsGerben Albert Van 'T Klooster, Piet Tom Bert Paul Wigerinck, Sandra De Meyer, Lieven Elvire Colette Baert, Herman Augustinus De Kock
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Abstract
A method for improving the pharmacokinetics of drugs, which are metabolized by cytochrome P450 monooxygenase is disclosed. More specifically it relates to a method for improving the pharmacokinetics of retroviral protease inhibitors and in particular for improving the pharmacokinetics of human immunodeficiency virus (HIV) protease inhibitors. A pharmaceutical composition and its use in the manufacture of a medicament for the inhibition or treatment of an HIV infection or AIDS in a human being are also part of the invention.
Claims1
A method of improving the pharmacokinetics of HIV-aspartyl protease inhibitor drug darunavir or saquinavir metabolized by cytochrome P450, or inhibited by P-glycoprotein, MRP1 or MRP2 activity by administering an effective amount of a compound having the formula
- or a compound having the formula
- to a mammal in need of such improvement.
Dependencies are inferred from the claim text.