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US 8,557,853 B2Granted
Aryl fluoroethyl ureas acting as alpha 2 adrenergic agents
AssigneeAllergan, Inc.
InventorsKen Chow, Wenkui K. Fang, Evelyn G. Corpuz, Daniel W. Gil, Michael E. Garst
Life of this patent
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Abstract
The invention provides well-defined aryl fluoroethyl ureas that are useful as selective alpha2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of alpha2 adrenergic receptors.
Claims6
A compound having the structure:
- or a pharmaceutically acceptable salt thereof wherein:
- R1 is H, alkyl, phenyl, or substituted phenyl;
- n is 0 or 1;
- Z1-Z6 are each independently C, CH, N, O, or S;
- p is 0 or 1;
- m is 1 to 5;
- each R2 is independently lower alkyl, halide, trifluoromethyl, lower alkenyl, lower alkynyl, cycloalkyl, —CN, —CH2CN, —CH2SR3, —CH2N(R3)2, —CH2OR3, —OR3, —SR3, —C(O)R4;
- wherein two R2 moieties taken together with carbon atoms to which each R2 is attached may form an aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclic, or substituted heterocyclic ring;
- each R3 is independently H, lower alkyl, or cycloalkyl;
- and
- each R4 is independently H, lower alkyl, cycloalkyl, alkoxy, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, or trifluoromethyl.
8 more elements
Dependencies are inferred from the claim text.