Spiro-piperidine inhibitors
AssigneeThe Trustees of the University of Pennsylvania
InventorsWilliam F. DeGrado, Jun Wang
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Abstract
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
Claims8
A method for treating infection by influenza A virus or an influenza A virus-affected disease state comprising the step of administering to a subject in need thereof a composition comprising a compound of formula (I):
- wherein
- R1 is hydrogen, alkyl, aralkyl, cycloalkyl-alkyl
- a1 is —CH2—;
- R2 and R3 are each independently C2-C4 alkyl,
- or,
- R2 and R3 taken together along with the carbon atom to which they are both attached form a 6 membered carbocyclic ring
- or a stereoisomer or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.