Aminopyrimidines useful as kinase inhibitors
AssigneeVertex Pharmaceuticals Incorporated
InventorsHayley Binch, Michael Mortimore, Damien Fraysse, Alistair Rutherford
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Abstract
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Claims8
A method of inhibiting Aurora protein kinase activity in a biological sample comprising contacting said biological sample with a compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is C1-3alkyl or cyclopropyl;
- R9 is halo, C1-3alkyl, —O—(C1-3alkyl), —S—(C1-3alkyl), or CF3;
- and p is 1-2.
A method of treating a proliferative disorder in a patient, wherein said proliferative disorder is a cancer selected from colon, gastric, or ovarian, said method comprises administering to said patient a compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is C1-3alkyl or cyclopropyl;
- R9 is halo, C1-3alkyl, —O—(C1-3alkyl), —S—(C1-3alkyl), or CF3;
- and p is 1-2.
A method of treating colon, gastric, or ovarian cancer in a subject in need thereof, comprising the sequential or co-administration of a compound of formula I or a pharmaceutically acceptable salt thereof, and another therapeutic agent:
- wherein:
- R2 is C1-3alkyl or cyclopropyl;
- R9 is halo, C1-3alkyl, —O—(C1-3alkyl), —S—(C1-3alkyl), or CF3;
- and p is 1-2.
A method of inhibiting Aurora protein kinase activity in a biological sample comprising contacting said biological sample with a compound selected from the following:
A method of treating a proliferative disorder in a patient, wherein the proliferative disorder is a cancer selected from colon, gastric, or ovarian, said method comprises administering to said patient a compound selected from the following:
Dependencies are inferred from the claim text.