Carboxamide, sulfonamide and amine compounds and methods for using the same

A compound having the structural formula

• or a pharmaceutically acceptable salt, prodrug or N-oxide thereof, wherein
• (a) “B” represents
• J is —N(R38)— and D is a carbon;
• (b) “B” represents
• in which X1 and X2 are independently a carbon or N, J is —O—, —N(R38)—, —CH2—, —CH(R26)— or —C(R26)2—, and D is a carbon or N;
• or
• (c) “B” represents “
• in which R14, if present, is selected from —(C1-C6 alkyl), —(C1-C6 halooalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, —(C0-C6 alkyl)-L—R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-C(O)R10, —(C0-C6 alkyl)-S(O)0-2R10, -halogen, —NO2 and —CN, R39 is H, —(C1-C4 alkyl), —C(O)—(C1-C4 alkyl) or —C(O)O—(C1-C4 alkyl), J is —O—, —N(R38)—, —CH2—, —CH(R26)— or —C(R26)2—, and D is a carbon or N;
• E is —C(O)—, —S(O)2— or a single bond;
• R1 is H, —(C1-C4 alkyl), —C(O)—(C1-C4 alkyl) or —C(O)O—(C1-C4 alkyl);
• R2 is -Hca, -Cak-N(R9)-G-R22 or —(C2-C8 alkyl)—N(R9)—R24 in which one or two carbons of the (C2-C8 alkyl) are optionally replaced by —O—, —S— or —N(R9)— and R24 is —R23, -G-R23, or —C(O)O—(C1-C6 alkyl), provided that two consecutive carbons of the (C2-C8 alkyl) are not replaced by —O—;
• each R3 is substituted on a benzo, pyrido or pyrazino carbon of the ring system denoted by “B” and is independently selected from —(C1-C6 alkyl), —(C1-C6 haloalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, —(C0-C6 alkyl)-L-R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-C(O)R10, —(C0-C6 alkyl)-S(O)0-2R10, -halogen, —NO2 and —CN;
• w is 0, 1, 2 or 3;
• each R4 is independently selected from —(C1-C6 alkyl), —(C1-C6 haloalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, —(C0-C6 alkyl)-L-R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-C(O)R10, —(C0-C6 alkyl)-S(O)0-2R10, -halogen, —NO2 and —CN, and two R4 on the same carbon optionally combine to form oxo;
• x is 0, 1, 2, 3 or 4;
• p is 0, 1, 2, 3 or 4;
• q is 0, 1, 2, 3 or 4;
• the sum of p and q is 1, 2, 3 or 4;
• T is —(C0-C6 alkyl)-L-R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-C(O)R10, —(C0-C6 alkyl)-S(O)0-2R10 or
• in which
• Q is —S(O)2— L or —(C0-C3 alkyl)-, in which each carbon of the —(C0-C3 alkyl)- is optionally and independently substituted with one or two R16;
• the ring system denoted by “A” is heteroaryl, aryl, cycloalkyl or heterocycloalkyl;
• each R5 is independently selected from —(C1-C6 alkyl), —(C1-C6 haloalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, —(C0-C6 alkyl)-L-R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-C(O)R10, —(C0-C6 alkyl)-S(O)0-2R10, —(C0-C6 alkyl)-C(O)R10, -halogen, —NO2 and —CN;
• and
• y is 0, 1, 2, 3 or 4;
• in which
• each L is independently selected from —NR9C(O)O—, —OC(O)NR9—, —NR9C(O)—NR9—, —NR9C(O)S—, —SC(O)NR9—, —NR9C(O)—, —C(O)—NR9—, —NR9C(S)NR—, —OC(S)NR9—, —NR9C(S)—NR9—, —NR9C(S)S—, —SC(S)NR9—, —NR9C(S)—, —C(S)NR9—, —SC(O)NR9—, —NR9C(S)—, —S(O)0-2—, —C(O)O, —OC(O)—, C(S)O—, —OC(S)—, —C(O)S—, —SC(O)—, —C(S)S—, —SC(S)—, —OC(O)O—, —SC(O)O—, —OC(O)S—, —SC(S)O—, —OC(S)S—, —NR9C(NR2)NR9—, —NR9SO2—, —SO2NR9— and —NR9SO2NR9—,
• each R7, R8 and R10 is independently selected from H, —(C1-C6 alkyl), —(C1-C6 haloalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, —(C0-C6 alkyl)-L-(C0-C6 alkyl), —(C0-C6 alkyl)-NR9—(C0-C6 alkyl), —(C0-C6 alkyl)-O—(C0-C6 alkyl), —(C0-C6 alkyl)-C(O)—(C0-C6 alkyl) and —(C0-C6 alkyl)-S(O)0-2—(C0-C6 alkyl),
• each R9 is independently selected from —H, —(C1-C4 alkyl), —C(O)—(C1-C4 alkyl) and —C(O)O—(C1-C4 alkyl),
• each G is independently —S(O)2—, L or —(C0-C3 alkyl)-, in which each carbon of the —(C0-C3 alkyl)- is optionally and independently substituted with one or two R16,
• each R16 is independently selected from —(C1-C6 alkyl), —(C1-C6 haloalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, —(C0-C6 alkyl)-L-R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-C(O)R10, —(C0-C6 alkyl)-S(O)0-2R10, -halogen, —NO2 and —CN, and optionally two of R16 on the same carbon combine to form oxo,
• each R26 is independently selected from —(C1-C6 alkyl), —(C1-C6 haloalkyl), —(C0-C6 alkyl)-Ar, —(C0-C6 alkyl)-Het, —(C0-C6 alkyl)-Cak, —(C0-C6 alkyl)-Hca, —(C0-C6 alkyl)-L-R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-C(O)R10, —(C0-C6 alkyl)-S(O)0-2R10, -halogen, —NO2 and —CN, and optionally two of R26 on the same carbon combine to form oxo,
• each R38 is independently selected from —H, —(C1-C4 alkyl), —C(O)—(C1-C4 alkyl) and —C(O)O—(C1-C4 alkyl),
• each R22 and R23 is independently Ar or Het,
• each Ar is an optionally substituted aryl,
• each Het is an optionally substituted heteroaryl,
• each Cak is an optionally substituted cycloalkyl,
• each Hca is an optionally substituted heterocycloalkyl, and
• each alkyl is optionally substituted.