Aurora kinase modulators and method of use

A compound of Formula I:

• or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein
• each of A1 and A2, independently, is CR2;
• each of A3, A4, A5 and A6, independently, is CR3;
• each of L1 and L2, independently, is —O—, —NR4—, —S—, —C(O)—, —S(O)—, —SO2— or —CR4R4—, wherein each R4, independently, is H, halo, OH, C1-6alkoxyl, NH—C1-6alkyl, CN or C1-6alkyl;
• each of A7 and A8, independently, is N;
• D′ is a pyrrole ring which in turn with the six-membered ring form a pyrrolo[3,2-b]pyridine ring optionally substituted independently with n number of substituents of R1;
• each R1, independently, is halo, haloalkyl, haloalkoxyl, oxo, CN, OH, SH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl, —SR9, —OR9, —NR9R9, —C(O)R9, —COOR9, —OC(O)R9, —C(O)C(O)R9, —C(O)NR9R9, —NR9C(O)R9, —NR9C(O)NR9R9, —NR9(COOR9), —OC(O)NR9R9, —S(O)2R9, —S(O)2NR9R9, —NR9S(O)2NR9R9, —NR9S(O)2R9 or a fully saturated or partially or fully unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from 0, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of R9;
• each R2, independently, is H, halo, haloalkyl, haloalkoxyl, CN, OH, SH, NO2, NH2, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or —C(O)R9;
• each R3, independently, is H, halo, haloalkyl, haloalkoxyl, CN, OH, SH, NO2, NH2, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or —C(O)R9;
• R6 is R9;
• R8 taken together with R7 and the carbon atoms to which they are attached form a benzene ring optionally substituted independently with 1-4 substituents of R9;
• each R9, independently, is H, halo, haloalkyl, haloalkoxyl, oxo, CN, OH, SH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl, SR10, OR10, NR4R10, C(O)R10, COOR10, C(O)NR4R10, NR4C(O)R10, NR4C(O)NR4R10, NR4(COOR10), S(O)2R10, S(O)2NR4R10, NR4S(O)2R10, NR4S(O)2NR4R10 or a fully saturated or partially or fully unsaturated 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from 0, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of le, halo, haloalkyl, haloalkoxyl, CN, NO2, NH2, OH, oxo, C1-6alkyl, C1-6alkoxyl, C3-6cycloalkyl, C1-10-alkylamino-, C1-10-dialkylamino-, benzyl or phenyl;
• R10 is H, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a fully saturated or partially or fully unsaturated 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, haloalkoxyl, CN, NO2, NH2, OH, oxo, C1-6alkyl, C1-6alkoxyl, C3-6cycloalkyl, C1-10-alkylamino-, C1-10-dialkylamino-, benzyl or phenyl;
• and
• n is 0, 1, 2, 3 or 4.