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US 8,557,812 B2Granted
Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
AssigneeThe Regents of the University of Michigan
InventorsShaomeng Wang, Guoping Wang, Guozhi Tang, Renxiao Wang, Zaneta Nikolovska-Coleska, Dajun Yang, Liang Xu
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Abstract
The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
Claims7
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.