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US 8,557,809 B2Granted
Triazolopyridine compounds as PIM kinase inhibitors
AssigneeArray BioPharma Inc.
InventorsShelley Allen, Robert Kirk DeLisle, Julie Marie Greschuk, Erik James Hicken, Joseph P. Lyssikatos, Fredrik P. Marmsater, Mark C. Munson, John E. Robinson, Qian Zhao
Life of this patent
Estimating the term…
Abstract
Compounds of Formula (I): I in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
Claims17
A compound of general Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R10 and R11 together with the N to which they are attached form a 4-8 membered heterocyclic ring optionally having an additional ring heteroatom selected from N and O, wherein the heterocyclic ring is optionally substituted with one or more R9 groups;
- each R9 is independently selected from halogen, (1-6C)alkyl, NRfRg, -(1-6C alkyl)NRhRi, ORj, (1-6C alkyl)ORk, C(O)NRmRn, C(O)O(1-6C alkyl), and -(1-6C alkyl)NRhC(O)O(1-6C alkyl);
- B is H, ORa, (1-6C alkyl)NRbRc, (1-6C alkyl)OH, NRbRc, or CH(OH)CH2OH;
- R1 is H, F, Cl, Br, methyl, ethyl, cyclopropyl or CN;
- R1a, R2, R3 and R4 are independently H, F, Cl, Br, methyl, ethyl, cyclopropyl or CN;
- R5 and R7 are independently H, F, Me or CN;
- R6 is H, F, Me, Br, CN, cyclopropyl or phenyl;
- Ra is H, (1-6C alkyl), -(1-6C alkyl)-O-(1-6C alkyl) or -(1-6C alkyl)-O-(3-6C cycloalkyl);
- each Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rk, and Rm is independently selected from H and (1-6C alkyl);
- and
- Rn is H, (1-6C alkyl) or O-(1-6C alkyl).
9 more elements
Dependencies are inferred from the claim text.