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US 8,557,804 B2Granted
Nicotinic receptor agonists for the treatment of inflammatory diseases
AssigneeUniversite Laval
InventorsYvon Cormier, Evelyne Israel-Assayag, Marie-Renee Blanchet, Rene C. Gaudreault, Philippe Labrie
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Abstract
Nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases, and pharmaceutical compositions including nicotine receptor agonists or analogs or derivatives thereof. Compounds of formula wherein R1, R2, Xa and Ya are as defined herein are also provided.
Claims22
A compound of formula:
- wherein
- R1 and R2 are independently lower alkyl of 1 to 10 carbon atoms,
- Xa is CH or N,
- Ya is one or more substituent selected from hydrogen, halogen, amidino, amido, azido, cyano, guanido, hydroxyl, nitroso, urea, sulfate, sulfite, sulfonate, sulphonamide, phosphate, phosphonate, acyl, acyloxy, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkylthio of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, alkanol of 1 to 6 carbon atoms, and aralkyl,
- n is 2,
- J is a counter ion.
3 more elements
A pharmaceutical composition comprising a compound of formula:
- wherein
- R1 and R2 are independently lower alkyl of 1 to 10 carbon atoms,
- Xa is CH or N,
- Ya is one or more substituent selected from halogen, amidino, amido, azido, cyano, guanido, hydroxyl, nitroso, urea, sulfate, sulfite, sulfonate, sulphonamide, phosphate, phosphonate, acyl, acyloxy, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkylthio of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, alkanol of 1 to 6 carbon atoms, and aralkyl,
- n is 2,
- J is a counter ion;
- and
- a pharmaceutically acceptable excipient.
5 more elements
A compound of formula:
- wherein
- R1 and R2 are independently lower alkyl of 1 to 10 carbon atoms,
- Xa is CH or N,
- Ya is one or more substituent selected from hydrogen, halogen, amidino, amido, azido, cyano, guanido, hydroxyl, nitroso, urea, sulfate, sulfite, sulfonate, sulphonamide, phosphate, phosphonate, acyl, acyloxy, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkylthio of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, alkanol of 1 to 6 carbon atoms, and aralkyl,
- n is 2,
- J is a sulfonate.
3 more elements
Dependencies are inferred from the claim text.