Triazolopyridine derivatives and their therapeutic use

A compound of formula (I), or a pharmaceutically acceptable salt thereof:

• wherein
• R1 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl which is optionally substituted, 5- or 6-membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II)
• wherein n is 1 or 2, and R3 and R4 are independently H or C1-C6 alkyl, or R3 and R4 taken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally comprising a further heteroatom selected from N and O;
• Y is —O— or —S(O)p— wherein p is 0, 1, or 2;
• A is an optionally substituted divalent arylene radical, a monocyclic heteroaryl radical, a bicyclic heteroarylene radical, a C3-C6 divalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R2NHC(═O)W—;
• W is a bond, —NH—or —C(RA)(RB), wherein RA and RB are independently H, methyl, ethyl, amino, hydroxyl, or halo;
• and
• R2 is a radical of formula (IIIA), (IIIB), or (IIIC):
• wherein
• m is 0 or 1,
• q is 0, 1, 2, or 3,
• T is —N═ or —CH═,
• R5 is H or F,
• R7 is —CH3, —C2H5, —CH2OH, —CH2SCH3, —SCH3, or -SC2H5,
• R8 is —CH3 or —C2H5, and
• each occurrence of R6 is independently H, C1-C6, hydroxyl, or halo;
• or a single occurrence or R6 is a radical of formula (IVA), (IVB), or (IVC)
• while any other occurrence of R6 is independently H, C1-C6 alkyl, hydroxyl or halo;
• and wherein, in R6,
• R61a and R61b are H, alkyl,
• or R61a and R61b are optionally joined together with the nitrogen to which they are attached to form a heterocyclic ring optionally comprising a further heteroatom selected from N and O.