Substituted 1-oxa-2,8-diaza-spiro [4,5] dec-2-ene derivatives and related treatment methods

A substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compound corresponding to formula I

• wherein
• R1 and R2 independently of one another represent H, C1-18-alkyl, C3-10-cycloalkyl, (C1-12-alkyl)-C3-10-cycloalkyl, aryl, (C1-12-alkyl)-aryl, heterocyclyl, (C1-12-alkyl)-heterocyclyl or NH—C(═O)-aryl, wherein at least one of the radicals R1 and R2 does not represent H,
• or
• together represent —(CR4R5)m—(CR6R7)n—Y—(CR8R9)p—(CR10R11)q— where m, n, p and q respectively=0, 1, 2, 3, 4 or 5, with the proviso that m+n≧1 and p+q≧1, or —CH2—CH2—C(-aryl)=CH—CH2—;
• R3 represents SO2R12;
• R4, R5, R6, R7, R8, R9, R10 and R11 independently of one another represent H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl or C(═O)R14;
• Y represents CR15R16, NR17 or O;
• R12 represents C1-10-alkyl, C3-10-cycloalkyl, (C1-6-alkyl)-C3-10-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl or NR18R19;
• R14 represents H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl or OR20;
• R15 and R16 independently of one another represent H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl or C(═O)R21;
• R17 represents H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl or C(═O)R22;
• R18 and R19 independently of one another represent H, C1-10-alkyl, C3-8-cycloalkyl, C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl or (C1-6-alkyl)-heterocyclyl;
• R20 represents H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl or (C1-6-alkyl)-heterocyclyl;
• R21 represents H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8 cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl or OR23;
• R22 represents H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl, (C1-6-alkyl)-heterocyclyl or OR24;
• and
• R23 and R24 independently of one another represent H, C1-10-alkyl, C3-8-cycloalkyl, (C1-6-alkyl)-C3-8-cycloalkyl, aryl, (C1-6-alkyl)-aryl, heterocyclyl or (C1-6-alkyl)-heterocyclyl,
• or a salt thereof with a physiologically tolerated acid.