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US 8,557,789 B2Granted
Method of treating inflammatory arthropathies with supressors of CPG oligonucleotides
AssigneeThe United States of America as represented by the Secretary of the Development of Health and Human Services
InventorsDennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
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Abstract
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
Claims15
A method of decreasing the production of one or more cytokines, comprising administering to a subject a therapeutically effective amount of an oligodeoxynucleotide of 12 to 100 nucleotides in length comprising SEQ ID NO:
- 4,
- thereby decreasing the production of the one or more cytokines, wherein one of the cytokines is interleukin-6, interleukin-12, interferon γ or a combination thereof.
Dependencies are inferred from the claim text.