Micro RNA (MiRNA) and neurofibromatosis type 1: a role in diagnosis and therapy
AssigneeMaine Institute of Human Genetics and Health
InventorsXijie Yu, Janet M. Hock
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Abstract
The present invention shows that levels of certain micro RNAs (MiRNAs) are altered in NF1 cell lines and NF1 tumor cell lines as compared to non-NF1 controls. Methods are provided, e.g., to diagnose NF1 and NF1 tumors. Methods are also provided to treat NF1, NF1 related cancer, and cognitive deficits resulting from NF1.
Claims10
A method of increasing neurofibromin expression in a neural cell of a subject having neurofibromatosis type 1 comprising contacting the cell with an effective amount of a miR-10b inhibitor which downmodulates the level of miR-10 miRNA in the neural cell, such that neurofibromin expression in the neural cell is increased.
Dependencies are inferred from the claim text.