Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
AssigneeBoehringer Ingelheim International GmbH
InventorsMatthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Achim Sauer, Leo Thomas
Life of this patent
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Abstract
Glucopyranosyl-substituted benzonitrile derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
Claims18
A glucopyranosyl-substituted benzonitrile derivative selected from the group consisting of:
- 2-(4-Ethyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile;
- 4-(β-D-glucopyranos-1-yl)-2-(4-methyl-benzyl)-benzonitrile;
- 4-(β-D-glucopyranos-1-yl)-2-(4-isopropyl-benzyl)-benzonitrile;
- 2-(4-Difluoromethoxy-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile;
- 2-(4-Difluoromethyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile;
- 2-(4-Cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile;
- 2-(4-Cyclobutyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile;
- and
- 4-(β-D-glucopyranos-1-yl)-2-(4-prop-1-yl-benzyl)-benzonitrile.
2-(4-Ethyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile.
4-(β-D-glucopyranos-1-yl)-2-(4-methyl-benzyl)-benzonitrile.
4-(β-D-glucopyranos-1-yl)-2-(4-isopropyl-benzyl)-benzonitrile.
2-(4-Difluoromethoxy-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile.
2-(4-Difluoromethyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile.
2-(4-Cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile.
2-(4-Cyclobutyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzonitrile.
4-(β-D-glucopyranos-1-yl)-2-(4-prop-1-yl-benzyl)-benzonitrile.
Dependencies are inferred from the claim text.