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US 8,557,772 B2Granted
Compositions having antiangiogenic activity and uses thereof
AssigneeThe Johns Hopkins University
InventorsAleksander S. Popel, Emmanouil D. Karagiannis
Life of this patent
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Abstract
Compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators are described. As discussed in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
Claims12
An isolated peptide or analog thereof consisting of
- a sequence having at least 85% amino acid sequence identity
- CXCL1:
- NGRKACLNPASPIVKKIIEKMLNS (SEQ ID NO:
- 102),
- wherein the peptide reduces blood vessel formation in a cell, tissue or organ.
2 more elements
A pharmaceutical composition comprising i) an isolated polypeptide having an amino acid sequence set forth in SEQ ID NO:
- 102, and ii) one or more peptides of SEQ ID NOS:
- 1-101 and 103-156.
Dependencies are inferred from the claim text.