3-hydroxyisothiazole 1-oxide derivatives

A compound of Formula (II)-4a:

• wherein p is an integer of 0 to 4;
• R1s are independently a group arbitrarily selected from a halogen atom, a C1-6 alkyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-6 alkenyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-6 alkynyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C1-6 alkoxy group which is optionally substituted with 1 to 5 substituent(s) RI and a cyano group;
• R2 is a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkoxy group or a cyano group;
• q is an integer of 0 to 4;
• s is an integer of 0 to 2;
• q1 is an integer of 0 to 3;
• r1 is an integer of 0 to 2;
• a ring A′ is an aryl group or a heteroaryl group;
• V is a single bond or an oxygen atom;
• R8s are independently a group arbitrarily selected from a C1-6 alkoxy group which is substituted with 1 to 5 substituent(s) RIII, an aralkyloxy group, a heterocyclic oxy group (the heterocyclic oxo group is optionally and arbitrarily substituted with 1 to 3 C1-6 alkyl group(s) or 1 to 3 oxo group(s)) or a heterocyclic group (the heterocyclic group is optionally and arbitrarily substituted with 1 to 3 C1-6 alkyl group(s));
• the substituent RIII is a group arbitrarily selected from —OH, a C1-6 alkoxy group, an aryl group (the aryl group is optionally and arbitrarily substituted with 1 to 3 halogen atom(s)), a heterocyclic group (the heterocyclic group is optionally and arbitrarily substituted with 1 to 3 C1-6 alkyl group(s) or 1 to 3 oxo group(s)), a group:
• —S(O)iRa (i is an integer of 0 to 2), a group:
• —SO2NRdRe, a group:
• —CONRdRe and a group:
• —NRb1Rc1;
• R9s are independently a group arbitrarily selected from a halogen atom, a cyano group, a C1-6 alkyl group (the C1-6 alkyl group is optionally and arbitrarily substituted with 1 to 5 halogen atom(s), 1 to 5 —OH or 1 to 5 C1-6 alkoxy group(s)), a C1-6 alkoxy group (the C1-6 alkoxy group is optionally and arbitrarily substituted with 1 to 5 halogen atom(s)), a C2-6 alkenyl group, a C2-7 alkanoyl group, a group:
• —S(O)iRa(i is an integer of 0 to 2), a group:
• —CONRdRe and a group:
• —NRb1Rc1;
• R11 and R12 are independently a halogen atom, —OH, a cyano group, a C1-6 alkyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-6 alkenyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C2-6 alkynyl group which is optionally substituted with 1 to 5 substituent(s) RI, a C1-6 alkoxy group which is optionally substituted with 1 to 5 substituent(s) RI, —SH, a group:
• —S(O)iRa (i is an integer of 0 to 2), or a group:
• —NRbRc;
• Ra is a group arbitrarily selected from a C1-6 alkyl group and a halogenated C1-6 alkyl group;
• Rb and Rc are independently a group arbitrarily selected from a hydrogen atom, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C2-7 alkanoyl group (the alkanoyl group is optionally substituted with —OH or a C1-6 alkoxy group), a C1-6 alkylsulfonyl group, an arylcarbonyl group and a heterocyclic carbonyl group, or Rb and Rc optionally form together with a nitrogen atom to which Rb and Rc are bonded, a 3- to 8-membered cyclic group, where in the cyclic group, one or two carbon atom(s) is(are) optionally substituted with an atom arbitrarily selected from an oxygen atom, a sulfur atom, and a nitrogen atom (the nitrogen atom is optionally substituted with a C1-6 alkyl group which is optionally substituted with 1 to 5 substituent(s) RI) or with a carbonyl group, and the cyclic group is optionally further substituted with 1 to 5 substituent(s) RII;
• the above-mentioned substituents RI are the same as or different from each other and are each a group arbitrarily selected from a halogen atom, —OH, a cyano group, a C1-6 alkoxy group (the C1-6 alkoxy group is optionally substituted with 1 to 5 halogen atom(s), 1 to 5 —OH, 1 to 5 C1-6 alkoxy group(s), 1 to 5 aryl group(s) (the aryl group is optionally and arbitrarily substituted with 1 to 3 halogen atom(s)), 1 to 5 heterocyclic group(s) (the heterocyclic group is optionally and arbitrarily substituted with 1 to 3 C1-6 alkyl group(s) or 1 to 3 oxo group(s)), 1 to 5 group(s):
• —S(O)iRa (i is an integer of 0 to 2), 1 to 5 group(s):
• —SO2NRdRe, 1 to 5 group(s):
• —CONRdRe or 1 to 5 group(s):
• —NRb1Rc1), a group:
• —NRb1Rc1 and a heterocyclic oxy group (the heterocyclic oxy group is optionally and arbitrarily substituted with 1 to 3 C1-6 alkyl group(s) or 1 to 3 oxo group(s));
• the above-mentioned substituents RII are the same as or different from each other and are each a group arbitrarily selected from the above-mentioned substituent RI, a C1-6 alkyl group (the C1-6 alkyl group is optionally and arbitrarily substituted with 1 to 5 halogen atom(s), 1 to 5 —OH, 1 to 5 C1-6 alkoxy group(s), 1 to 5 group(s):
• —S(O)iRa (i is an integer of 0 to 2), 1 to 5 group(s):
• —SO2NRdRe, 1 to 5 group(s):
• —CONRdRe or 1 to 5 group(s):
• —NRb1Rc1), a C2-6 alkenyl group, a C2-7 alkanoyl group, an aralkyloxy group, a heterocyclic group (the heterocyclic group is optionally and arbitrarily substituted with 1 to 3 C1-6 alkyl group(s) or 1 to 3 oxo group(s)), a heterocyclic carbonyl group (the heterocyclic carbonyl group is optionally and arbitrarily substituted with 1 to 3 C1-6 alkyl group(s) or 1 to 3 oxo group(s)), a group:
• —S(O)iRa (i is an integer of 0 to 2), a group:
• —CONRdRe, and a group:
• —CONRdRe1;
• Rd and Re are independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group is optionally substituted with 1 to 5 halogen atom(s), 1 to 5 —OH or 1 to 5 C1-6 alkoxyl group(s));
• Rel is a C1-6 alkyl group (the C1-6 alkyl group is optionally substituted with 1 to 5 —OH, 1 to 5 C1-6 alkoxyl group(s), 1 to 5 aryl group(s) (the aryl group is optionally substituted with 1 to 3 halogen atom(s)), 1 to 5 heterocyclic group(s) (the heterocyclic group is optionally substituted with 1 to 3 C1-6 alkyl group or 1 to 3 oxo group(s)), 1 to 5 —S(O)iRa group(s) (i is an integer of 0 to 2), 1 to 5 —SO2NRdRe group(s), 1 to 5 —CONRdRe group(s) or 1 to 5 —NRb1Rc1 group(s);
• Rb1 and Rc1 are independently a group arbitrarily selected from a hydrogen atom, a C1-6 alkyl group, a C2-7 alkanoyl group and a C1-6 alkylsulfonyl group, or Rb1 and Rc1 optionally form together with a nitrogen atom to which Rb1 and Rc1 are bonded, a 3- to 8-membered cyclic group, where in the cyclic group, one or two carbon atom(s) is(are) optionally substituted with an atom arbitrarily selected from an oxygen atom, a sulfur atom, and a nitrogen atom (the nitrogen atom is optionally substituted with a C1-6 alkyl group) or with a carbonyl group;
• or a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable solvate of the salt or a pharmaceutically acceptable solvate of the compound.