Methods of modulating immune function
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsMartha Karen Newell, Evan Newell
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Abstract
The invention relates to methods for modulating the immune function through targeting of CLIP molecules as well as gamma delta T cells. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, transplant and cell graft rejection, cancer, bacterial infection, HIV infection, and AIDS, as well as novel methods of diagnosis and of introducing a treatment regimen into a subject.
Claims7
A method for treating HIV infection comprising:
- contacting a CLIP molecule expressing cell with an inhibitor of γδT cell expansion, activation and/or effector function in an effective amount to treat the HIV infection, wherein the inhibitor of δγT cell expansion, activation and/or effector function is a CLIP activity inhibitor, wherein the CLIP activity inhibitor is a peptide that displaces CLIP, wherein the agent that displaces CLIP is FRIMAVLAS (SEQ ID NO. 2).
A method for treating a subject infected with HIV comprising:
- administering to the subject a CLIP inhibitor in an effective amount to reduce CLIP function in a CLIP molecule expressing cell of the subject wherein the CLIP inhibitor is FRIMAVLAS (SEQ ID NO. 2).
Dependencies are inferred from the claim text.