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US 8,557,763 B2Granted
Synthetic peptides that enhance tight junction permeability
AssigneeAlba Therapeutics Corporation
InventorsAmir Tamiz, Min Li
Life of this patent
Estimating the term…
Abstract
The present invention provides novel peptides that facilitate the opening of mammalian tight junctions. i.e. tight junction agonists. Th present invention also provides methods for the treatment of disease by administering to a subject suffereing from the disease a composition comprising a peptide tight junction agonist of the invention in combination with a therapeutically effective amount of an active agent.
Claims6
A peptide tight junction agonist comprising the amino acid sequence of SEQ ID NO:1, with the proviso that the amino acid sequence has 2 or 3 amino acid substitutions with respect to SEQ ID NO:
- 1, wherein:
- the position corresponding to position 1 of SEQ ID NO:1 is Phe,
- the position corresponding to position 2 of SEQ ID NO:1 is AllylGly, and the agonist is from 6 to 10 amino acids in length.
Dependencies are inferred from the claim text.