Chiral heterogeneous catalyst for assymmetric nitroaldol reaction
AssigneeCouncil of Scientific and Industrial Research
InventorsSayed H. R. Abdi, Rukhsana I. Kureshy, Noor-Ui H. Khan, Hari C. Bajaj, Vishal J. Mayani, Arpan K. Shah
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Abstract
The present invention relates to the preparation of highly efficient chiral heterogeneous catalyst for asymmetric nitroaldol reaction, wherein Henry reactions of various aldehydes such as aromatic, aliphatic, α,β-unsaturated aldehydes, alicyclic aldehydes and nitroalkenes were carried out to produce optically active β-nitroalcohols in high yield, with moderate to excellent enantioselectivity (ee up to >99%) in presence of a base and an optically active chiral heterogeneous catalyst.
Claims21
A chiral heterogeneous catalyst of general formula 1,
- Wherein,
- R1=R2=H or CH3
- R3=Cl, I, F, Br, OCH3, CH3, OC2H5, NO2
- R4=H, CH3, C2H5
- x=1, 2
- Z=CH3CO2−, Cl−, OH−, NO3−.
Dependencies are inferred from the claim text.