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US 8,557,601 B2Granted
Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
AssigneeThe Regents of the University of California
InventorsKenneth N. Raymond, Jide Xu, Evan G. Moore, Eric J. Werner
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Abstract
The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.
Claims37
A luminescent complex between a lanthanide ion and an organic ligand comprising the subunit of Formula I:
- wherein
- R1, R2, R3 and R4 are members independently selected from H, an aryl group substituent, a linker to a scaffold moiety and a linker to a functional moiety;
- wherein at least one of R1, R2, R3 and R4 is a linker to a scaffold moiety;
- and
- M+3 is a lanthanide ion forming said luminescent complex with said organic ligand, with the proviso that said lanthanide is not gadolinium (Gd).
2 more elements
Dependencies are inferred from the claim text.