US 8,557,574 B2 · Fungal growth inhibitor

Abstract

A very safe and useful agent for inhibiting fungal growth and the like are provided by the present invention. Specifically, the present invention provides (1) an agent for inhibiting fungal growth comprising hyaluronic acid or a salt thereof excluding a heavy metal salt as the active ingredient, and a method for inhibiting fungal growth, which comprises at least a step of allowing hyaluronic acid or a salt thereof excluding a heavy metal salt to contact with a fungus, (2) an agent for reinforcing activity of inhibiting fungal growth possessed by a cell, which comprises a DNA encoding a hyaluronic acid synthase as the active ingredient, (3) a method for reinforcing activity of inhibiting fungal growth of a cell, which comprises at least a step of transfecting a DNA encoding a hyaluronic acid synthase into the cell, and (4) a method for inhibiting fungal growth, which comprises at least a step of allowing a cell transfected with a DNA encoding a hyaluronic acid synthase to contact with a fungus.

Claims6

Dependent claims

A method for inhibiting fungal growth in cell culture, comprising culturing a cell transfected with a DNA encoding a hyaluronic acid synthase in a culture medium, under conditions permissive for fungal growth, in the presence of a fungus;

wherein the growth of said fungus during said culturing is reduced in comparison to the growth of said fungus under said conditions when said cell is not transfected with said DNA;
wherein the concentration of hyaluronic acid in said culture medium during said culturing reaches at least 347 ng/ml;
and wherein said fungus is from the genus Candida.

Dependencies are inferred from the claim text.

Fungal growth inhibitor

Life of this patent

Fungal growth inhibitor

Life of this patent

Abstract

Claims6