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US 8,557,546 B2Granted
Recombinant human G-CSF dimer and use thereof for the treatment of neurological diseases
AssigneeGeneron (Shanghai) Corporation Ltd.
InventorsXiaoqiang Yan, Zhihua Huang, Hongzhou Yang, Bill N. C. Sun, Yuliang Huang
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Abstract
This invention relates to a recombinant human G-CSF (rhG-CSF) dimer and its use in the treatment of neurological disorder. In particular, upon ischemic neural injury in animal, this invention can be used to protect neurons with the use of rhG-CSF dimer such that function of injured nerves can be restored. Serum half-life of G-CSF dimer of this invention is prolonged and the biological activity thereof is increased.
Claims11
A human granulocyte colony-stimulating factor (G-CSF) dimer of formula (1):
- M1-L-M2 (1)
- wherein
- M1 is a first monomer of G-CSF;
- M2 is a second monomer of G-CSF;
- and
- L is a linker connecting said first monomer and said second monomer and disposed therebetween;
- wherein said G-CSF dimer retains the biological activity of G-CSF and has a serum half-life of more than twice of that of either said first or said second monomer;
- wherein said dimer is produced by two G-CSF-Fc complexes;
- each of said G-CSF-Fc complex comprises the amino acid sequence of SEQ ID NO:
- 6.
7 more elements
Dependencies are inferred from the claim text.