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US 8,557,545 B2Granted
Modified phosphatases
AssigneeAM-Pharma B.V.
InventorsMarkwin Paul Velders, Luigi Johannes Cornelius Jonk, Willem Raaben, Marty Bernardus Fransiscus Wulferink
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Abstract
The invention relates to phosphatases and more in specific to (genetically) modified phosphatases, pharmaceutical compositions comprising (genetically) modified phosphatases and the use of (genetically) modified phosphatases for treating or curing for example sepsis, inflammatory bowel disease or other inflammatory diseases, or renal failure. The invention further relates to a method for producing phosphatases.
Claims15
An alkaline phosphatase, wherein the alkaline phosphatase is isolated or recombinant and comprises:
- a human intestinal alkaline phosphatase (ALPI) wherein the crown domain of the human ALPI, corresponding to amino acids 366-430 of SEQ ID NO:2, is replaced with the crown domain of a human placental alkaline phosphatase (ALPP), corresponding to amino acids 366-430 of SEQ ID NO:1,
- wherein the alkaline phosphatase has dephosphorylation activity.
Dependencies are inferred from the claim text.