Use of cellular extracts for skin rejuvenation

A method of treating a subject comprising:

• contacting the skin of said subject with a water soluble, cytoplasmic fraction of salmon eggs in an amount effective to cause one or more effects selected from the group consisting of reduction of fine lines in the skin, normalization of skin color, increasing skin water content and hydration, decreasing or normalizing the amount of sebum in the skin, decreasing production of melanin, increasing collagen protein production, increasing collagen gene expression, increasing adult stem cell proliferation, increasing cellular metabolism of carbohydrates, increasing cellular metabolism of lipids, prevention of apoptosis, increasing angiogenesis, upregulation the cell cycle of cells, increasing angiogenesis, increasing the hair cycle, increasing follicular development, and increasing cell proliferation.