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US 8,557,281 B2Granted
Water-swellable polymers
AssigneeFerring B.V.
InventorsJanet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
Life of this patent
Estimating the term…
Abstract
A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swell able linear polymer obtainable by reacting together: (a) a polyethylene oxide; (b) a C5 to C20 diol; and (c) a diisocyanate; and (II) a releasable pharmaceutically active agent.
Claims23
A pharmaceutical controlled release composition in solid dosage form, comprises:
- (I) a water-swellable linear polymer obtainable by reacting
- (a) a polyethylene oxide;
- (b) a C8 to C15 alkanediol;
- and
- (c) a diisocyanate;
- and
- (II) a releasable pharmaceutically active agent;
- wherein the polyethylene oxide has a number average molecular weight of 3000 to 40,000 and the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.1-1.5 to 1 to 1.1-2.5.
5 more elements
A pharmaceutical controlled release composition in solid dosage form, comprising:
- (I) a water-swellable linear polymer obtained by reacting
- (a) a polyethylene oxide;
- (b) a C5 to C20 alkanediol;
- and
- (c) a diisocyanate;
- and
- (II) a releasable pharmaceutically active agent;
- wherein the water-swellable linear polymer has a water swelling percentage of 250% to 2000%, wherein the polyethylene oxide has a number average molecular weight of 3000 to 40,000, and the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.1-1.5 to 1 to 1.1-2.5.
5 more elements
A pharmaceutical controlled release composition in solid dosage form, consisting of:
- (I) a water-swellable linear polymer obtained by reacting
- (a) a polyethylene oxide;
- (b) a C5 to C20 alkanediol;
- and
- (c) a diisocyanate;
- and
- (II) a releasable pharmaceutically active agent;
- wherein the water-swellable linear polymer is a random copolymer and the dosage form is a pessary or suppository, wherein the polyethylene oxide has a number average molecular weight of 3000 to 40,000, and the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.1-1.5 to 1 to 1.1-2.5.
5 more elements
Dependencies are inferred from the claim text.