Transdermal therapeutic system with crystallization-inhibiting protective film (release liner)
AssigneeBayer Intellectual Property GmbH
InventorsStefan Bracht, Ildiko Terebesi, Thomas Langguth
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Abstract
The invention relates to pharmaceutical formulations, in particular to transdermal therapeutic systems, which are characterized in that little or no active ingredient crystallizes out at the interface between the removable protective film (release liner) and the active-ingredient-containing matrix.
Claims18
Solid transdermal therapeutic system with at least one active-ingredient containing matrix layer which comprises a polymer matrix supersaturated with gestodene or a gestodene ester, and optionally comprising ethinylestradiol, and a removable protective film directly adjacent to the matrix which is a silicone- or fluoropolymer-coated polyester removable film,
- Wherein the fraction of gestodene or gestodene ester in the form of amorphous or crystalline particles at the interface between the removable protective film and the active-ingredient-containing matrix or in the active-ingredient-containing matrix is on less than 2% of the area of the system, and
- wherein the matrix is free from solubility promoters, crystallization inhibitors and dispersants.
Dependencies are inferred from the claim text.