Device for local and/or regional delivery employing liquid formulations of therapeutic agents

A method for creating a drug delivery device comprising:

• coating an expandable member with a liquid formulation, the liquid formulation comprising a taxane in a pharmaceutically effective dosage, one or more pharmaceutically acceptable solubility enhancers and water in the range from about one percent by weight to about seventy percent by weight, the liquid formulation comprising a final solution of taxane in the range from about 0.05 mg/ml to about 15 mg/ml;
• and drying the coating on the expandable member.

A method for treating restenosis comprising:

• introducing an expandable member into the vasculature, the expandable member having an external surface and configured such that the external surface makes contact with surrounding tissue when the expandable member is expanded, the expandable member comprising a liquid formulation of a therapeutic agent affixed to the external surface of the expandable member and configured for release into surrounding tissue when the external surface of the expandable member makes contact with the expandable member, the liquid formulation comprising the liquid formulation comprising a taxane in a pharmaceutically effective dosage, one or more pharmaceutically acceptable solubility enhancers and water in the range from about one percent by weight to about seventy percent by weight, the liquid formulation comprising a final solution of taxane in the range from about 0.05 mg/ml to about 15 mg/ml;
• expanding the expandable device such that the external surface is in contact with the surrounding tissue for a period of between about ten seconds to about five minutes;
• and contracting and removing the expandable device from the vasculature.