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US 8,557,252 B2Granted
Genetically stable attenuated polioviruses comprising multiple mutations in domain V of the 5′ noncoding region
AssigneeThe Secretary of State for Health
InventorAndrew MacAdam
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Abstract
The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5′ non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.
Claims10
A poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5′ non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.
Dependencies are inferred from the claim text.